ARCYRIAFLAVIN A
- Product Name
- ARCYRIAFLAVIN A
- CAS No.
- 118458-54-1
- Chemical Name
- ARCYRIAFLAVIN A
- Synonyms
- ARCYRIAFLAVIN A;ARCYRIAFLAVIN A, SYNTHETIC;12,13-DIHYDRO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7(6H)-DIONE;5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro-
- CBNumber
- CB5311390
- Molecular Formula
- C20H11N3O2
- Formula Weight
- 325.32
- MOL File
- 118458-54-1.mol
ARCYRIAFLAVIN A Property
- Melting point:
- >200 °C
- Density
- 1.621±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Orange to red solid.
- pka
- 10.74±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- 13516
- Product name
- Arcyriaflavin A
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 13516
- Product name
- Arcyriaflavin A
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 13516
- Product name
- Arcyriaflavin A
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 2457
- Product name
- ArcyriaflavinA
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $223
- Updated
- 2021/12/16
- Product number
- A766578
- Product name
- ArcyriaflavinA
- Packaging
- 2.5mg
- Price
- $520
- Updated
- 2021/12/16
ARCYRIAFLAVIN A Chemical Properties,Usage,Production
Uses
Arcyriaflavin A is a potent inhibitor of CDK4/cyclin D1.
Definition
ChEBI: LSM-3627 is an indolocarbazole.
Biological Activity
Potent inhibitor of cdk4/cyclin D1 (IC 50 = 59 nM). Also active against CaM kinase II (IC 50 = 25 nM) but displays selectivity over several other kinases in vitro (IC 50 values for inhibition of PKA and PKC are > 2 and > 100 μ M respectively). Inhibits human cytomegalovirus (HCMV) replication in vitro (IC 50 = 200 nM).
in vitro
arcyriaflavin a is a potent, selective inhibitor of hcmv replication in cell culture, and the anti-hcmv activity appeared no relation to the inhibition of protein kinase c. the imide nh was identified to be essential for anti-hcmv activity [1]. arcyriaflavin a also has been showed the inhibitory activity against d1/cdk4 with a ic50 of 59 nm. based on x-ray co-crystal structure of staurosporine and the human cdk2, the acidic proton of the maleimide moiety and the carbonyl group play critical roles by acting as a hydrogen bond donor and acceptor in the atp binding pocket of cdk2 [2].
IC 50
0.2 μm for hcmv [1], 0.14 μm for d1–cdk4 [2]
References
[1] slater mj, cockerill s, baxter r, bonser rw, gohil k, gowrie c, robinson je, littler e, parry n, randall r, snowden w. indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. bioorg med chem. 1999 jun;7(6):1067-74.
[2] zhu g, conner s, zhou x, shih c, brooks hb, considine e, dempsey ja, ogg c, patel b, schultz rm, spencer cd, teicher b, watkins sa. synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin d1/cdk4 inhibitors. bioorg med chem lett. 2003 apr 7;13(7):1231-5.